Utjecaj bolesti površine oka na kvalitetu života kod pacijenata s glaukomom koji koriste lokalnu intraokularnu terapiju

master's thesis

• Title (english): Impact of ocular surface disease on vision related QOL in patients with glaucoma using opical intraocular therapy
• Author: Corina Ivkić
• Mentor: Tina Runjić (mentor)
• Mentor: Katia Novak Lauš (mentor)
• Committee member: Tina Runjić (predsjednik povjerenstva)
• Committee member: Katia Novak Lauš (član povjerenstva)
• Committee member: Ante Bilić-Prcić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Education and Rehabilitation Sciences; Zagreb
• Defense date and country: 2017-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: SOCIAL SCIENCES; Education/Rehabilitation Sciences

Abstract

Glaukom je kronična bolest koju karakterizira progresivna neuropatija vidnog živca i jedan je od vodećih uzroka sljepoće. Osobe s glaukomom su u većem riziku za razvoj bolesti površine oka (OSD – a) obzirom na visoku prevalenciju navedenih bolesti u starijoj populaciji. Također, lokalna antiglaukomska terapija u obliku kapi, kao najčešći oblik liječenja, često se povezuje sa simptomima OSD – a. Dugoročna terapija može dodatno pojačati simptome OSD – a te, uz funkcionalne poteškoće glaukoma, narušiti kvalitetu života osoba. Cilj ovog istraživanja je bio ispitati povezanost OSD – a i samoprocjenjene kvalitete života povezane s vidom kod osoba s glaukomom koje koriste lokalnu antiglaukomsku terapiju te provjeriti postoje li razlike obzirom na spol, dob te oblik terapije. U istraživanju je sudjelovao 81 ispitanik, pacijent Kabineta za glaukom, KBC – a Sestre milosrdnice u Zagrebu. Podaci su prikupljeni uz pomoć novokonstruiranog Općeg upitnika, Upitnika bolesti površine oka (OSDI) i Upitnika vizualnog funkcioniranja (NEI – VFQ – 39) te su obrađeni pomoću ROBDIS programa, IBM SPSS Statistics i kvazikanoničke korelacije. Rezultati su pokazali da se uznapredovali OSD javlja kod 37% ispitanika, dok ih također 37% pokazuje normalne vrijednosti. Blago oštećenje ima 18,5%, a umjereno 7,4% ispitanika. Najčešća nuspojava uz medikamentoznu terapiju je peckanje (43,21%), koju potom slijedi pojačano crvenilo očiju (23,46%) te suhoća oka (22,22%). Kvazikanonička korelacijska analiza je pokazala da postoji statistički značajna povezanost (p < 0,01) između OSD – a i kvalitete života povezane s vidom. Nakon izvršene robustne diskriminacijske analize, pronađene su značajne razlike u kvaliteti života i OSD – u između ispitanika obzirom na spol i dob te medikamentoznu terapiju. Navedeni nalazi podupiru rezultate svjetskih istraživanja koji napominju kako OSD može narušiti uspješnost terapije te naposljetku, negativno utjecati na kvalitetu života pacijenata s glaukomom koji koriste lokalnu antiglaukomsku terapiju. Na kraju, ističe se potreba za daljnjim istraživanjima navedene problematike koja će pružiti implikacije za poboljšanje kvalitete života glaukomskih pacijenata.

Abstract (english)

Glaucoma is a chronic disease characterised by progressive optic nerve damage and is one of the leading cause of blindness. Glaucoma patients are presumably at a higher risk for developing ocular surface disease (OSD), as both diseases are more common in older patients. Also, topical antiglaucoma drops, as the most common form of treatment, is often associated with OSD symptoms. Long term use of topical treatment could additionally increase symptoms of OSD and, with functional disabilities, affect patient`s quality of life. The purpose of this study was to investigate the relationship between OSD and the self perceived vision – related quality of life in patients with glaucoma using topical antiglaucoma therapy and to determine differences between gender, age and form of therapy. The study included 81 glaucoma patients recruited from the Cabinet for Glaucoma, Department of Ophthalmology, University Hospital Sestre milosrdnice in Zagreb. The data were collected by newly constructed General questionnaire, Ocular Surface Disease Index questionnaire (OSDI) and Visual Function Questionnaire (NEI – VFQ – 39). The data collected were quantitatively analyzed by using ROBDIS, IBM SPSS Statistics software and quazi – canonical analysis. According to the results, 37% patients had severe, while 37% of them showed normal OSDI score. Mild OSDI score had 18,5%, and moderate 7,4%. The most common side effect of therapy is tingling in eye (43,21%), followed by increased redness od the eye (23,46%) and eye dryness (22,22%). Quazi - canonical analysis showed that there is a statistically significant association (p <0.01) between OSD and the vision – related quality of life. After robust discriminatory analysis, significant differences in the quality of life and OSD between gender and age groups and medication therapy were found. These findings support the results of global research that obscure that OSD can undermine the success of therapy and ultimately negatively affect the quality of life of glaucoma patients using local antiglaucoma therapy. Finally, the need for further research into this subject is emphasized, which will provide implications for improving the quality of life of glaucoma patients.

• Keywords: glaukom; kvaliteta života; bolest površine oka (OSD); lokalna antiglaukomska terapija
• Keywords (english): glaucoma; quality of life; ocular surface disease (OSD); local antiglaucoma therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:158:001760
• Study programme: Title: Educational Rehabilitation; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra edukacijske rehabilitacije (magistar/magistra edukacijske rehabilitacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-07-17 07:41:14